Drug interactions
Aripiprazole + Voclosporin
Severity: Moderate
Aripiprazole and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT interval prolongation, so using them together may add to the risk of ventricular arrhythmia such as torsades de pointes. The risk is greater with electrolyte disturbances, structural heart disease or other QT-prolonging drugs.
What this interaction means in plain words
Aripiprazole and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Voclosporin belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization (QT prolongation).
What to do
Obtain a baseline ECG and monitor the QTc during combined therapy, and correct potassium and magnesium abnormalities. Reassess the combination if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Aripiprazole with Voclosporin?
MediHelp rates the interaction as moderate. Aripiprazole and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT interval prolongation, so using them together may add to the risk of ventricular arrhythmia such as torsades de pointes. The risk is greater with electrolyte disturbances, structural heart disease or other QT-prolonging drugs.
How serious is the interaction between Aripiprazole and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc during combined therapy, and correct potassium and magnesium abnormalities. Reassess the combination if the QTc becomes markedly prolonged.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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