Drug interactions
Aripiprazole + Zafirlukast
Severity: Minor
Aripiprazole and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast might modestly raise aripiprazole exposure through CYP3A4 inhibition, but the effect is theoretical and likely small. Aripiprazole is also cleared by CYP2D6, which limits the impact.
What this interaction means in plain words
Aripiprazole and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Zafirlukast belongs to Respiratory.
Why it happens
Weak CYP3A4 inhibition by zafirlukast may slightly reduce aripiprazole metabolism.
What to do
No routine dose adjustment is required. Monitor for sedation, akathisia or orthostasis if symptoms emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Zafirlukast?
MediHelp rates the interaction as minor. Aripiprazole and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast might modestly raise aripiprazole exposure through CYP3A4 inhibition, but the effect is theoretical and likely small. Aripiprazole is also cleared by CYP2D6, which limits the impact.
How serious is the interaction between Aripiprazole and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is required. Monitor for sedation, akathisia or orthostasis if symptoms emerge.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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