Drug interactions
Armodafinil + Belladonna and opium
Severity: Moderate
Armodafinil and Belladonna and opium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna and opium suppositories contain an opioid and an anticholinergic, both causing sedation. Armodafinil may mask sedation without reversing opioid respiratory depression. Armodafinil may also modestly reduce exposure to CYP3A4-metabolised opioids.
What this interaction means in plain words
Armodafinil and Belladonna and opium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing pharmacodynamic effects on arousal, plus weak CYP3A4 induction.
What to do
Monitor respiratory rate and pain control. Do not use alertness as a marker of safe opioid dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Belladonna and opium?
MediHelp rates the interaction as moderate. Armodafinil and Belladonna and opium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna and opium suppositories contain an opioid and an anticholinergic, both causing sedation. Armodafinil may mask sedation without reversing opioid respiratory depression. Armodafinil may also modestly reduce exposure to CYP3A4-metabolised opioids.
How serious is the interaction between Armodafinil and Belladonna and opium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate and pain control. Do not use alertness as a marker of safe opioid dosing.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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