Drug interactions
Armodafinil + Benzphetamine
Severity: Moderate
Armodafinil and Benzphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are CNS stimulants and benzphetamine is a sympathomimetic anorectic. Combined use may increase insomnia, anxiety, tachycardia and blood pressure elevation. Cardiovascular risk is greater in those with existing disease.
What this interaction means in plain words
Armodafinil and Benzphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS stimulation and sympathomimetic effects.
What to do
Monitor blood pressure, heart rate and sleep. Avoid in patients with uncontrolled hypertension or arrhythmias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Benzphetamine?
MediHelp rates the interaction as moderate. Armodafinil and Benzphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are CNS stimulants and benzphetamine is a sympathomimetic anorectic. Combined use may increase insomnia, anxiety, tachycardia and blood pressure elevation. Cardiovascular risk is greater in those with existing disease.
How serious is the interaction between Armodafinil and Benzphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and sleep. Avoid in patients with uncontrolled hypertension or arrhythmias.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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