Drug interactions
Armodafinil + Buprenorphine long-acting
Severity: Moderate
Armodafinil and Buprenorphine long-acting: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may reduce buprenorphine levels from the long-acting injection. Inadequate exposure could lead to withdrawal or relapse risk.
What this interaction means in plain words
Armodafinil and Buprenorphine long-acting can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Armodafinil induces CYP3A4, increasing buprenorphine metabolism.
What to do
Monitor for withdrawal symptoms and adequacy of treatment response; if inadequate, return to a titratable buprenorphine formulation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Buprenorphine long-acting?
MediHelp rates the interaction as moderate. Armodafinil and Buprenorphine long-acting can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil may reduce buprenorphine levels from the long-acting injection. Inadequate exposure could lead to withdrawal or relapse risk.
How serious is the interaction between Armodafinil and Buprenorphine long-acting?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for withdrawal symptoms and adequacy of treatment response; if inadequate, return to a titratable buprenorphine formulation.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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