Drug interactions
Armodafinil + Cannabidiol
Severity: Minor
Armodafinil and Cannabidiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may inhibit CYP2C19 and could raise concentrations of cannabidiol's active metabolite. This may increase sedation and other adverse effects.
What this interaction means in plain words
Armodafinil and Cannabidiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Cannabidiol belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C19 reduces metabolism of cannabidiol and its active metabolite.
What to do
Monitor for somnolence, and reduce the cannabidiol dose if adverse effects develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Tacrolimus Major
- Cannabidiol + Valproic acid Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Armodafinil with Cannabidiol?
MediHelp rates the interaction as minor. Armodafinil and Cannabidiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil may inhibit CYP2C19 and could raise concentrations of cannabidiol's active metabolite. This may increase sedation and other adverse effects.
How serious is the interaction between Armodafinil and Cannabidiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for somnolence, and reduce the cannabidiol dose if adverse effects develop.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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