Drug interactions
Armodafinil + Clemastine
Severity: Minor
Armodafinil and Clemastine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine is a sedating first-generation antihistamine, and armodafinil is a wakefulness-promoting agent. Their opposing CNS effects may reduce the benefit of armodafinil or make sedation less predictable.
What this interaction means in plain words
Armodafinil and Clemastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Clemastine belongs to Respiratory.
Why it happens
Opposing pharmacodynamic effects on CNS arousal (histamine H1 blockade versus wake promotion).
What to do
Monitor alertness and consider a non-sedating antihistamine if clemastine undermines the response to armodafinil.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Clemastine
Frequently asked questions
Can I take Armodafinil with Clemastine?
MediHelp rates the interaction as minor. Armodafinil and Clemastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clemastine is a sedating first-generation antihistamine, and armodafinil is a wakefulness-promoting agent. Their opposing CNS effects may reduce the benefit of armodafinil or make sedation less predictable.
How serious is the interaction between Armodafinil and Clemastine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor alertness and consider a non-sedating antihistamine if clemastine undermines the response to armodafinil.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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