Drug interactions
Armodafinil + Conivaptan
Severity: Minor
Armodafinil and Conivaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 substrate and armodafinil is a CYP3A4 inducer. Armodafinil may lower conivaptan exposure and reduce its effect on serum sodium. Conivaptan is given for short periods, limiting overall effect.
What this interaction means in plain words
Armodafinil and Conivaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 induction by armodafinil, increasing conivaptan clearance.
What to do
Monitor serum sodium frequently during conivaptan infusion. Adjust therapy if the sodium response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Conivaptan?
MediHelp rates the interaction as minor. Armodafinil and Conivaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Conivaptan is a CYP3A4 substrate and armodafinil is a CYP3A4 inducer. Armodafinil may lower conivaptan exposure and reduce its effect on serum sodium. Conivaptan is given for short periods, limiting overall effect.
How serious is the interaction between Armodafinil and Conivaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium frequently during conivaptan infusion. Adjust therapy if the sodium response is inadequate.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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