Drug interactions
Armodafinil + Danazol
Severity: Moderate
Armodafinil and Danazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol inhibits CYP3A4 and may raise armodafinil exposure, though armodafinil is only partly CYP3A4 dependent. Armodafinil in turn may reduce levels of sensitive CYP3A4 substrates. The net effect is generally modest.
What this interaction means in plain words
Armodafinil and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits CYP3A4, reducing armodafinil clearance, while armodafinil weakly induces CYP3A4.
What to do
Monitor for armodafinil adverse effects such as anxiety, insomnia, headache and elevated blood pressure. Reduce the armodafinil dose if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Danazol?
MediHelp rates the interaction as moderate. Armodafinil and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol inhibits CYP3A4 and may raise armodafinil exposure, though armodafinil is only partly CYP3A4 dependent. Armodafinil in turn may reduce levels of sensitive CYP3A4 substrates. The net effect is generally modest.
How serious is the interaction between Armodafinil and Danazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for armodafinil adverse effects such as anxiety, insomnia, headache and elevated blood pressure. Reduce the armodafinil dose if these occur.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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