Drug interactions
Armodafinil + Dextromoramide
Severity: Minor
Armodafinil and Dextromoramide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextromoramide is a potent opioid that causes sedation and respiratory depression, and armodafinil does not reverse these effects. Wakefulness from armodafinil may mask sedation, but opioid respiratory depression persists.
What this interaction means in plain words
Armodafinil and Dextromoramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing effects on arousal; armodafinil does not antagonize opioid respiratory depression.
What to do
Dose the opioid by pain response and respiratory status, not by alertness. Monitor respiratory rate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Dextromoramide?
MediHelp rates the interaction as minor. Armodafinil and Dextromoramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dextromoramide is a potent opioid that causes sedation and respiratory depression, and armodafinil does not reverse these effects. Wakefulness from armodafinil may mask sedation, but opioid respiratory depression persists.
How serious is the interaction between Armodafinil and Dextromoramide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Dose the opioid by pain response and respiratory status, not by alertness. Monitor respiratory rate.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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