Drug interactions
Armodafinil + Dienogest / estradiol valerate
Severity: Moderate
Armodafinil and Dienogest / estradiol valerate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may lower hormone exposure through CYP3A4 induction, which could reduce contraceptive effectiveness and cause breakthrough bleeding. The effect can persist for a time after armodafinil is stopped.
What this interaction means in plain words
Armodafinil and Dienogest / estradiol valerate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Armodafinil induces CYP3A4, increasing metabolism of estradiol and dienogest.
What to do
Advise an additional non-hormonal contraceptive method during armodafinil use and for about a month after stopping. Consider a method not affected by enzyme induction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Dienogest / estradiol valerate?
MediHelp rates the interaction as moderate. Armodafinil and Dienogest / estradiol valerate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil may lower hormone exposure through CYP3A4 induction, which could reduce contraceptive effectiveness and cause breakthrough bleeding. The effect can persist for a time after armodafinil is stopped.
How serious is the interaction between Armodafinil and Dienogest / estradiol valerate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal contraceptive method during armodafinil use and for about a month after stopping. Consider a method not affected by enzyme induction.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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