Drug interactions
Armodafinil + Dihydroergotamine intranasal
Severity: Moderate
Armodafinil and Dihydroergotamine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may reduce systemic dihydroergotamine exposure from the nasal spray through CYP3A4 induction, potentially weakening migraine relief. The clinical effect is expected to be modest.
What this interaction means in plain words
Armodafinil and Dihydroergotamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Armodafinil induces CYP3A4, increasing the metabolism of dihydroergotamine.
What to do
Monitor for loss of headache relief and consider an alternative acute migraine treatment if response declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Armodafinil and Dihydroergotamine intranasal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Dihydroergotamine intranasal?
MediHelp rates the interaction as moderate. Armodafinil and Dihydroergotamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil may reduce systemic dihydroergotamine exposure from the nasal spray through CYP3A4 induction, potentially weakening migraine relief. The clinical effect is expected to be modest.
How serious is the interaction between Armodafinil and Dihydroergotamine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of headache relief and consider an alternative acute migraine treatment if response declines.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
