Drug interactions
Armodafinil + Donepezil
Severity: Minor
Armodafinil and Donepezil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may modestly reduce donepezil concentrations by inducing CYP3A4, which could weaken cognitive benefit. The effect is likely small.
What this interaction means in plain words
Armodafinil and Donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Donepezil belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases the metabolism of donepezil.
What to do
Monitor cognitive and functional response; adjust donepezil dose only if benefit declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Armodafinil with Donepezil?
MediHelp rates the interaction as minor. Armodafinil and Donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil may modestly reduce donepezil concentrations by inducing CYP3A4, which could weaken cognitive benefit. The effect is likely small.
How serious is the interaction between Armodafinil and Donepezil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cognitive and functional response; adjust donepezil dose only if benefit declines.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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