Drug interactions
Armodafinil + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Moderate
Armodafinil and Elvitegravir / cobicistat / emtricitabine / tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat strongly inhibits CYP3A4, which contributes to armodafinil clearance, so armodafinil levels may rise. This could increase adverse effects such as anxiety, insomnia and headache.
What this interaction means in plain words
Armodafinil and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP3A4-mediated metabolism of armodafinil.
What to do
Monitor for stimulant adverse effects and blood pressure, and reduce the armodafinil dose if not tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as moderate. Armodafinil and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat strongly inhibits CYP3A4, which contributes to armodafinil clearance, so armodafinil levels may rise. This could increase adverse effects such as anxiety, insomnia and headache.
How serious is the interaction between Armodafinil and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for stimulant adverse effects and blood pressure, and reduce the armodafinil dose if not tolerated.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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