Drug interactions
Armodafinil + Esketamine intranasal
Severity: Moderate
Armodafinil and Esketamine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine transiently raises blood pressure and heart rate, and armodafinil, a wake-promoting stimulant, can also raise blood pressure. Together they may produce larger or more sustained hemodynamic increases.
What this interaction means in plain words
Armodafinil and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pressor and sympathomimetic pharmacodynamic effects.
What to do
Measure blood pressure before dosing and again after esketamine administration, as labeling advises with psychostimulants. Avoid the combination in patients with poorly controlled hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Esketamine intranasal?
MediHelp rates the interaction as moderate. Armodafinil and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine transiently raises blood pressure and heart rate, and armodafinil, a wake-promoting stimulant, can also raise blood pressure. Together they may produce larger or more sustained hemodynamic increases.
How serious is the interaction between Armodafinil and Esketamine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure blood pressure before dosing and again after esketamine administration, as labeling advises with psychostimulants. Avoid the combination in patients with poorly controlled hypertension.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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