Drug interactions
Armodafinil + Estazolam
Severity: Minor
Armodafinil and Estazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil promotes wakefulness while estazolam is a sedative-hypnotic, so the two have opposing effects and the hypnotic effect of estazolam may be blunted. Armodafinil may also modestly induce CYP3A4 and lower estazolam exposure.
What this interaction means in plain words
Armodafinil and Estazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CNS pharmacodynamic effects plus possible weak CYP3A4 induction by armodafinil.
What to do
Assess whether estazolam is still effective for sleep, and adjust the dose only if response is inadequate. Do not rely on armodafinil to offset benzodiazepine sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Estazolam?
MediHelp rates the interaction as minor. Armodafinil and Estazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil promotes wakefulness while estazolam is a sedative-hypnotic, so the two have opposing effects and the hypnotic effect of estazolam may be blunted. Armodafinil may also modestly induce CYP3A4 and lower estazolam exposure.
How serious is the interaction between Armodafinil and Estazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess whether estazolam is still effective for sleep, and adjust the dose only if response is inadequate. Do not rely on armodafinil to offset benzodiazepine sedation.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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