Drug interactions
Armodafinil + Ethinyl estradiol-levonorgestrel
Severity: Moderate
Armodafinil and Ethinyl estradiol-levonorgestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil can induce CYP3A4 and lower exposure to ethinyl estradiol, which may reduce contraceptive efficacy. Effects may persist after stopping.
What this interaction means in plain words
Armodafinil and Ethinyl estradiol-levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Ethinyl estradiol-levonorgestrel belongs to Endocrine.
Why it happens
CYP3A4 induction by armodafinil increases clearance of ethinyl estradiol.
What to do
Use an additional non-hormonal contraceptive during armodafinil therapy and for one month after discontinuation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Ethinyl estradiol-levonorgestrel?
MediHelp rates the interaction as moderate. Armodafinil and Ethinyl estradiol-levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil can induce CYP3A4 and lower exposure to ethinyl estradiol, which may reduce contraceptive efficacy. Effects may persist after stopping.
How serious is the interaction between Armodafinil and Ethinyl estradiol-levonorgestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an additional non-hormonal contraceptive during armodafinil therapy and for one month after discontinuation.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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