Drug interactions
Armodafinil + Fexinidazole
Severity: Moderate
Armodafinil and Fexinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole inhibits CYP3A4 and may raise armodafinil concentrations, increasing adverse effects such as anxiety, insomnia, headache and cardiovascular stimulation. Fexinidazole also prolongs the QT interval, adding to the overall risk.
What this interaction means in plain words
Armodafinil and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibits CYP3A4, reducing the metabolism of armodafinil.
What to do
Monitor for armodafinil adverse effects and consider holding or reducing armodafinil during the short fexinidazole course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Armodafinil and Fexinidazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Fexinidazole?
MediHelp rates the interaction as moderate. Armodafinil and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole inhibits CYP3A4 and may raise armodafinil concentrations, increasing adverse effects such as anxiety, insomnia, headache and cardiovascular stimulation. Fexinidazole also prolongs the QT interval, adding to the overall risk.
How serious is the interaction between Armodafinil and Fexinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for armodafinil adverse effects and consider holding or reducing armodafinil during the short fexinidazole course.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
