Drug interactions
Armodafinil + Flurazepam
Severity: Minor
Armodafinil and Flurazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil promotes wakefulness and flurazepam promotes sleep, so they may counteract each other. Armodafinil may also induce CYP3A4 slightly and lower exposure to flurazepam's active metabolites.
What this interaction means in plain words
Armodafinil and Flurazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CNS pharmacodynamic effects plus possible weak CYP3A4 induction.
What to do
Evaluate hypnotic effectiveness and adjust therapy if sleep is not adequate. Avoid using one agent to offset the other.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Flurazepam?
MediHelp rates the interaction as minor. Armodafinil and Flurazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil promotes wakefulness and flurazepam promotes sleep, so they may counteract each other. Armodafinil may also induce CYP3A4 slightly and lower exposure to flurazepam's active metabolites.
How serious is the interaction between Armodafinil and Flurazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Evaluate hypnotic effectiveness and adjust therapy if sleep is not adequate. Avoid using one agent to offset the other.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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