Drug interactions
Armodafinil + Fosamprenavir
Severity: Moderate
Armodafinil and Fosamprenavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may weakly induce CYP3A4 and lower amprenavir concentrations, the active form of fosamprenavir. Reduced antiretroviral exposure could contribute to virologic failure or resistance.
What this interaction means in plain words
Armodafinil and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by armodafinil increases amprenavir clearance.
What to do
Monitor HIV viral load and consider therapeutic drug monitoring if available. Review the regimen if virologic response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Fosamprenavir?
MediHelp rates the interaction as moderate. Armodafinil and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil may weakly induce CYP3A4 and lower amprenavir concentrations, the active form of fosamprenavir. Reduced antiretroviral exposure could contribute to virologic failure or resistance.
How serious is the interaction between Armodafinil and Fosamprenavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and consider therapeutic drug monitoring if available. Review the regimen if virologic response is lost.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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