Drug interactions
Armodafinil + Hydrocortisone
Severity: Minor
Armodafinil and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a modest CYP3A4 inducer and may lower hydrocortisone exposure. This could reduce corticosteroid effect, notably in patients on replacement therapy.
What this interaction means in plain words
Armodafinil and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Hydrocortisone belongs to Endocrine.
Why it happens
Armodafinil induces CYP3A4, increasing hydrocortisone metabolism.
What to do
Monitor clinical response and adjust hydrocortisone if symptoms of under-replacement appear in adrenal insufficiency.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Hydrocortisone?
MediHelp rates the interaction as minor. Armodafinil and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a modest CYP3A4 inducer and may lower hydrocortisone exposure. This could reduce corticosteroid effect, notably in patients on replacement therapy.
How serious is the interaction between Armodafinil and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and adjust hydrocortisone if symptoms of under-replacement appear in adrenal insufficiency.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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