Drug interactions
Armodafinil + Hydroxyprogesterone caproate
Severity: Minor
Armodafinil and Hydroxyprogesterone caproate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyprogesterone caproate is partly metabolized by CYP3A4, so armodafinil's weak induction may lower its levels. The clinical significance is uncertain but reduced efficacy is possible.
What this interaction means in plain words
Armodafinil and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 induction by armodafinil accelerates progestin metabolism.
What to do
Monitor for reduced therapeutic effect and consider an alternative if response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Hydroxyprogesterone caproate?
MediHelp rates the interaction as minor. Armodafinil and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydroxyprogesterone caproate is partly metabolized by CYP3A4, so armodafinil's weak induction may lower its levels. The clinical significance is uncertain but reduced efficacy is possible.
How serious is the interaction between Armodafinil and Hydroxyprogesterone caproate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced therapeutic effect and consider an alternative if response is inadequate.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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