Drug interactions
Armodafinil + Indinavir
Severity: Moderate
Armodafinil and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a CYP3A4 substrate with a narrow margin for maintaining adequate trough levels. Armodafinil's weak CYP3A4 induction may lower indinavir exposure and risk loss of viral suppression.
What this interaction means in plain words
Armodafinil and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by armodafinil increases indinavir clearance.
What to do
Monitor viral load and consider therapeutic drug monitoring of indinavir if armodafinil is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Indinavir?
MediHelp rates the interaction as moderate. Armodafinil and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir is a CYP3A4 substrate with a narrow margin for maintaining adequate trough levels. Armodafinil's weak CYP3A4 induction may lower indinavir exposure and risk loss of viral suppression.
How serious is the interaction between Armodafinil and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor viral load and consider therapeutic drug monitoring of indinavir if armodafinil is required.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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