Drug interactions
Armodafinil + Iobenguane i
Severity: Moderate
Armodafinil and Iobenguane i: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drugs that affect catecholamine uptake or storage can reduce iobenguane uptake into tumor cells and diminish therapeutic or imaging efficacy. Armodafinil is a dopamine reuptake inhibitor and sympathomimetic-like stimulant, so interference is plausible.
What this interaction means in plain words
Armodafinil and Iobenguane i can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Armodafinil inhibits dopamine reuptake, and may compete with or impair norepinephrine transporter-mediated iobenguane uptake.
What to do
Withhold armodafinil for at least five half-lives before iobenguane dosimetry or therapy and for at least 7 days after each dose, per product labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Armodafinil and Iobenguane i, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Iobenguane i?
MediHelp rates the interaction as moderate. Armodafinil and Iobenguane i can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drugs that affect catecholamine uptake or storage can reduce iobenguane uptake into tumor cells and diminish therapeutic or imaging efficacy. Armodafinil is a dopamine reuptake inhibitor and sympathomimetic-like stimulant, so interference is plausible.
How serious is the interaction between Armodafinil and Iobenguane i?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Withhold armodafinil for at least five half-lives before iobenguane dosimetry or therapy and for at least 7 days after each dose, per product labeling.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
