Drug interactions
Armodafinil + Irinotecan liposomal
Severity: Moderate
Armodafinil and Irinotecan liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irinotecan is activated and also inactivated via CYP3A4, and inducers can lower exposure to the active metabolite SN-38, reducing efficacy. Strong inducers are advised against in labeling, and moderate inducers carry a similar though smaller concern.
What this interaction means in plain words
Armodafinil and Irinotecan liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Armodafinil induces CYP3A4, increasing oxidative metabolism of irinotecan to inactive metabolites.
What to do
Consider a non-inducing alternative to armodafinil and monitor tumor response and toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Irinotecan liposomal?
MediHelp rates the interaction as moderate. Armodafinil and Irinotecan liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Irinotecan is activated and also inactivated via CYP3A4, and inducers can lower exposure to the active metabolite SN-38, reducing efficacy. Strong inducers are advised against in labeling, and moderate inducers carry a similar though smaller concern.
How serious is the interaction between Armodafinil and Irinotecan liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-inducing alternative to armodafinil and monitor tumor response and toxicity.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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