Drug interactions
Armodafinil + Ixabepilone
Severity: Moderate
Armodafinil and Ixabepilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ixabepilone is cleared mainly by CYP3A4, and strong inducers can lower its exposure. Armodafinil is a weak inducer, so the effect is probably limited but could reduce antitumor efficacy.
What this interaction means in plain words
Armodafinil and Ixabepilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Weak CYP3A4 induction by armodafinil increases ixabepilone clearance.
What to do
Monitor tumor response and toxicity, and consider a non-inducing alternative to armodafinil where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Ixabepilone?
MediHelp rates the interaction as moderate. Armodafinil and Ixabepilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ixabepilone is cleared mainly by CYP3A4, and strong inducers can lower its exposure. Armodafinil is a weak inducer, so the effect is probably limited but could reduce antitumor efficacy.
How serious is the interaction between Armodafinil and Ixabepilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and toxicity, and consider a non-inducing alternative to armodafinil where possible.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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