Drug interactions
Armodafinil + Lofepramine
Severity: Minor
Armodafinil and Lofepramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine, a tricyclic antidepressant, may be sedating while armodafinil promotes wakefulness, so effects may oppose each other. Tricyclics may also add to cardiovascular stimulation and lower the seizure threshold.
What this interaction means in plain words
Armodafinil and Lofepramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CNS effects with possible additive cardiovascular effects.
What to do
Monitor heart rate, blood pressure and mood, and review the regimen if insomnia or tachycardia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Lofepramine?
MediHelp rates the interaction as minor. Armodafinil and Lofepramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lofepramine, a tricyclic antidepressant, may be sedating while armodafinil promotes wakefulness, so effects may oppose each other. Tricyclics may also add to cardiovascular stimulation and lower the seizure threshold.
How serious is the interaction between Armodafinil and Lofepramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and mood, and review the regimen if insomnia or tachycardia develops.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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