Drug interactions
Armodafinil + Loprazolam
Severity: Minor
Armodafinil and Loprazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil promotes wakefulness while loprazolam is a sedative hypnotic benzodiazepine, so their clinical effects oppose one another. The net effect on alertness is unpredictable, and the benzodiazepine's psychomotor impairment may persist despite subjective wakefulness.
What this interaction means in plain words
Armodafinil and Loprazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic effects on central nervous system arousal; no established pharmacokinetic mechanism.
What to do
Do not rely on armodafinil to offset benzodiazepine sedation and counsel the patient about residual impairment when driving. Reassess the need for the hypnotic if wakefulness-promoting therapy is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Loprazolam?
MediHelp rates the interaction as minor. Armodafinil and Loprazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil promotes wakefulness while loprazolam is a sedative hypnotic benzodiazepine, so their clinical effects oppose one another. The net effect on alertness is unpredictable, and the benzodiazepine's psychomotor impairment may persist despite subjective wakefulness.
How serious is the interaction between Armodafinil and Loprazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not rely on armodafinil to offset benzodiazepine sedation and counsel the patient about residual impairment when driving. Reassess the need for the hypnotic if wakefulness-promoting therapy is required.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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