Drug interactions
Armodafinil + Lormetazepam
Severity: Minor
Armodafinil and Lormetazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a wakefulness-promoting agent and lormetazepam is a sedative hypnotic benzodiazepine, so they have opposing effects. Alertness may be unpredictable, and impairment from the benzodiazepine can persist even when the patient feels awake.
What this interaction means in plain words
Armodafinil and Lormetazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic effects on central arousal; no established pharmacokinetic mechanism.
What to do
Do not use armodafinil to counteract hypnotic sedation, and warn the patient about residual psychomotor impairment. Review whether both drugs are needed together.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Lormetazepam?
MediHelp rates the interaction as minor. Armodafinil and Lormetazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a wakefulness-promoting agent and lormetazepam is a sedative hypnotic benzodiazepine, so they have opposing effects. Alertness may be unpredictable, and impairment from the benzodiazepine can persist even when the patient feels awake.
How serious is the interaction between Armodafinil and Lormetazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use armodafinil to counteract hypnotic sedation, and warn the patient about residual psychomotor impairment. Review whether both drugs are needed together.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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