Drug interactions
Armodafinil + Lumefantrine
Severity: Moderate
Armodafinil and Lumefantrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak to moderate CYP3A4 inducer and lumefantrine is metabolised mainly by CYP3A4. Lower lumefantrine exposure could reduce antimalarial efficacy and raise the risk of treatment failure or recrudescence.
What this interaction means in plain words
Armodafinil and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Armodafinil induces CYP3A4, increasing the metabolism of lumefantrine.
What to do
Consider holding armodafinil during the artemether-lumefantrine course, or monitor closely for treatment response and recurrent parasitemia. Ensure doses are taken with fatty food to maximise absorption.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Lumefantrine?
MediHelp rates the interaction as moderate. Armodafinil and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil is a weak to moderate CYP3A4 inducer and lumefantrine is metabolised mainly by CYP3A4. Lower lumefantrine exposure could reduce antimalarial efficacy and raise the risk of treatment failure or recrudescence.
How serious is the interaction between Armodafinil and Lumefantrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider holding armodafinil during the artemether-lumefantrine course, or monitor closely for treatment response and recurrent parasitemia. Ensure doses are taken with fatty food to maximise absorption.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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