Drug interactions
Armodafinil + Meprobamate
Severity: Minor
Armodafinil and Meprobamate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meprobamate is a sedative anxiolytic and armodafinil promotes wakefulness, so the drugs have opposing effects. Net alertness is unpredictable and meprobamate impairment may persist.
What this interaction means in plain words
Armodafinil and Meprobamate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic effects on central arousal; no established pharmacokinetic mechanism.
What to do
Do not use armodafinil to offset meprobamate sedation, and counsel the patient about residual psychomotor impairment. Review the need for both agents.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Meprobamate?
MediHelp rates the interaction as minor. Armodafinil and Meprobamate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Meprobamate is a sedative anxiolytic and armodafinil promotes wakefulness, so the drugs have opposing effects. Net alertness is unpredictable and meprobamate impairment may persist.
How serious is the interaction between Armodafinil and Meprobamate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use armodafinil to offset meprobamate sedation, and counsel the patient about residual psychomotor impairment. Review the need for both agents.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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