Drug interactions
Armodafinil + Olanzapine
Severity: Moderate
Armodafinil and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may modestly lower olanzapine exposure through enzyme induction, and its wake-promoting effect opposes olanzapine sedation. Armodafinil may also aggravate psychosis or agitation in susceptible patients, so loss of antipsychotic control is a concern.
What this interaction means in plain words
Armodafinil and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Possible CYP1A2 induction by armodafinil plus opposing CNS effects.
What to do
Monitor psychiatric symptoms and olanzapine response, and adjust the olanzapine dose if control worsens. Watch for agitation, insomnia or anxiety.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Olanzapine
Frequently asked questions
Can I take Armodafinil with Olanzapine?
MediHelp rates the interaction as moderate. Armodafinil and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil may modestly lower olanzapine exposure through enzyme induction, and its wake-promoting effect opposes olanzapine sedation. Armodafinil may also aggravate psychosis or agitation in susceptible patients, so loss of antipsychotic control is a concern.
How serious is the interaction between Armodafinil and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric symptoms and olanzapine response, and adjust the olanzapine dose if control worsens. Watch for agitation, insomnia or anxiety.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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