Drug interactions
Armodafinil + Papaveretum
Severity: Moderate
Armodafinil and Papaveretum: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum contains opioid alkaloids that cause sedation and respiratory depression, whereas armodafinil promotes wakefulness. The stimulant does not reverse opioid respiratory depression and may hide sedation.
What this interaction means in plain words
Armodafinil and Papaveretum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing central pharmacodynamic effects; armodafinil does not antagonise opioid effects.
What to do
Do not use armodafinil to offset opioid sedation. Monitor respiratory rate and sedation level.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Papaveretum?
MediHelp rates the interaction as moderate. Armodafinil and Papaveretum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Papaveretum contains opioid alkaloids that cause sedation and respiratory depression, whereas armodafinil promotes wakefulness. The stimulant does not reverse opioid respiratory depression and may hide sedation.
How serious is the interaction between Armodafinil and Papaveretum?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use armodafinil to offset opioid sedation. Monitor respiratory rate and sedation level.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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