Drug interactions
Armodafinil + Phendimetrazine
Severity: Moderate
Armodafinil and Phendimetrazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both armodafinil and phendimetrazine are central stimulants with sympathomimetic activity. Combined use can increase blood pressure and heart rate and cause insomnia, anxiety and palpitations.
What this interaction means in plain words
Armodafinil and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central stimulant and sympathomimetic pharmacodynamic effects.
What to do
Monitor blood pressure, heart rate and neuropsychiatric symptoms. Avoid the combination in patients with cardiovascular disease or anxiety disorders.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Phendimetrazine?
MediHelp rates the interaction as moderate. Armodafinil and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both armodafinil and phendimetrazine are central stimulants with sympathomimetic activity. Combined use can increase blood pressure and heart rate and cause insomnia, anxiety and palpitations.
How serious is the interaction between Armodafinil and Phendimetrazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and neuropsychiatric symptoms. Avoid the combination in patients with cardiovascular disease or anxiety disorders.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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