Drug interactions
Armodafinil + Pimozide
Severity: Moderate
Armodafinil and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide is a sedating antipsychotic with QT-prolonging potential, while armodafinil is a stimulant that can increase heart rate and cause palpitations. Armodafinil may also reduce pimozide exposure through enzyme induction. The net effects are unpredictable and cardiac effects deserve attention.
What this interaction means in plain words
Armodafinil and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Opposing CNS effects, with possible CYP3A4 induction lowering pimozide levels and additive cardiovascular stimulation.
What to do
Obtain a baseline ECG and monitor heart rate, QTc and symptom control. Adjust the pimozide dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Armodafinil with Pimozide?
MediHelp rates the interaction as moderate. Armodafinil and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimozide is a sedating antipsychotic with QT-prolonging potential, while armodafinil is a stimulant that can increase heart rate and cause palpitations. Armodafinil may also reduce pimozide exposure through enzyme induction. The net effects are unpredictable and cardiac effects deserve attention.
How serious is the interaction between Armodafinil and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor heart rate, QTc and symptom control. Adjust the pimozide dose according to response.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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