Drug interactions
Armodafinil + Protriptyline
Severity: Moderate
Armodafinil and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protriptyline is a tricyclic antidepressant that is generally less sedating but has anticholinergic and cardiovascular effects. Armodafinil may add to tachycardia and insomnia, and CYP2C19 inhibition by armodafinil could modestly raise tricyclic levels.
What this interaction means in plain words
Armodafinil and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive stimulant and cardiovascular effects, plus possible CYP2C19 inhibition by armodafinil.
What to do
Monitor heart rate, blood pressure and tricyclic adverse effects. Reduce the protriptyline dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Protriptyline?
MediHelp rates the interaction as moderate. Armodafinil and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protriptyline is a tricyclic antidepressant that is generally less sedating but has anticholinergic and cardiovascular effects. Armodafinil may add to tachycardia and insomnia, and CYP2C19 inhibition by armodafinil could modestly raise tricyclic levels.
How serious is the interaction between Armodafinil and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and tricyclic adverse effects. Reduce the protriptyline dose if toxicity appears.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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