Drug interactions
Armodafinil + Quazepam
Severity: Minor
Armodafinil and Quazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quazepam is a long-acting benzodiazepine hypnotic, and armodafinil promotes wakefulness, so they pharmacodynamically oppose each other. Armodafinil may reduce the hypnotic effect or mask drowsiness without removing impairment.
What this interaction means in plain words
Armodafinil and Quazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CNS effects; armodafinil may also weakly induce CYP3A4 involved in benzodiazepine clearance.
What to do
Counsel patients that residual impairment can persist despite feeling alert. Reassess the need for both drugs if insomnia or daytime sedation worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Quazepam?
MediHelp rates the interaction as minor. Armodafinil and Quazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quazepam is a long-acting benzodiazepine hypnotic, and armodafinil promotes wakefulness, so they pharmacodynamically oppose each other. Armodafinil may reduce the hypnotic effect or mask drowsiness without removing impairment.
How serious is the interaction between Armodafinil and Quazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients that residual impairment can persist despite feeling alert. Reassess the need for both drugs if insomnia or daytime sedation worsens.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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