Drug interactions
Armodafinil + Rifampin
Severity: Moderate
Armodafinil and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a potent inducer of CYP3A4 and P-glycoprotein and can lower armodafinil exposure. This may reduce wakefulness-promoting efficacy.
What this interaction means in plain words
Armodafinil and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induces CYP3A4 and P-glycoprotein, increasing armodafinil clearance.
What to do
Monitor clinical response and consider increasing the armodafinil dose during rifampin therapy. Reduce the dose again after rifampin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Rifampin?
MediHelp rates the interaction as moderate. Armodafinil and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin is a potent inducer of CYP3A4 and P-glycoprotein and can lower armodafinil exposure. This may reduce wakefulness-promoting efficacy.
How serious is the interaction between Armodafinil and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider increasing the armodafinil dose during rifampin therapy. Reduce the dose again after rifampin is stopped.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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