Drug interactions
Armodafinil + Sildenafil
Severity: Minor
Armodafinil and Sildenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak CYP3A4 inducer and may modestly lower sildenafil exposure. The clinical effect is usually small.
What this interaction means in plain words
Armodafinil and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Sildenafil belongs to Genitourinary.
Why it happens
Weak induction of CYP3A4 by armodafinil increases sildenafil clearance.
What to do
Monitor for reduced sildenafil response and adjust the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Sildenafil?
MediHelp rates the interaction as minor. Armodafinil and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a weak CYP3A4 inducer and may modestly lower sildenafil exposure. The clinical effect is usually small.
How serious is the interaction between Armodafinil and Sildenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced sildenafil response and adjust the dose if needed.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
Full monographs, dosing and an interaction checker in the MediHelp app
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