Drug interactions
Armodafinil + Sufentanil sl
Severity: Moderate
Armodafinil and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may lower sufentanil concentrations and reduce analgesia, possibly causing withdrawal in dependent patients. Stopping armodafinil later could raise sufentanil levels and increase opioid effects.
What this interaction means in plain words
Armodafinil and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Armodafinil induces CYP3A4, increasing sufentanil metabolism.
What to do
Monitor for reduced analgesia or withdrawal; after armodafinil is stopped, watch for sedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Sufentanil sl?
MediHelp rates the interaction as moderate. Armodafinil and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil may lower sufentanil concentrations and reduce analgesia, possibly causing withdrawal in dependent patients. Stopping armodafinil later could raise sufentanil levels and increase opioid effects.
How serious is the interaction between Armodafinil and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced analgesia or withdrawal; after armodafinil is stopped, watch for sedation and respiratory depression.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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