Drug interactions
Armodafinil + Thiothixene
Severity: Moderate
Armodafinil and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiothixene is an antipsychotic that can cause sedation, and armodafinil may counteract this. Stimulants may also worsen psychosis or agitation in susceptible patients.
What this interaction means in plain words
Armodafinil and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS effects, with possible worsening of psychotic symptoms from armodafinil stimulation.
What to do
Monitor psychiatric status, including agitation, anxiety and psychotic symptoms. Reassess armodafinil if symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Thiothixene?
MediHelp rates the interaction as moderate. Armodafinil and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiothixene is an antipsychotic that can cause sedation, and armodafinil may counteract this. Stimulants may also worsen psychosis or agitation in susceptible patients.
How serious is the interaction between Armodafinil and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric status, including agitation, anxiety and psychotic symptoms. Reassess armodafinil if symptoms emerge.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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