Drug interactions
Armodafinil + Yohimbine
Severity: Moderate
Armodafinil and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are CNS stimulants. Together they may cause additive anxiety, insomnia, restlessness, and increases in heart rate and blood pressure.
What this interaction means in plain words
Armodafinil and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive stimulant effects: yohimbine blocks alpha-2 adrenoceptors and increases noradrenergic outflow, while armodafinil promotes wakefulness via dopaminergic and related pathways.
What to do
Avoid combining when possible. If used together, monitor blood pressure, heart rate, and anxiety or sleep disturbance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Yohimbine?
MediHelp rates the interaction as moderate. Armodafinil and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are CNS stimulants. Together they may cause additive anxiety, insomnia, restlessness, and increases in heart rate and blood pressure.
How serious is the interaction between Armodafinil and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining when possible. If used together, monitor blood pressure, heart rate, and anxiety or sleep disturbance.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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