Drug interactions
Armodafinil + Zaleplon
Severity: Minor
Armodafinil and Zaleplon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak CYP3A4 inducer and may slightly reduce zaleplon exposure, since CYP3A4 is a minor pathway for zaleplon. Any loss of hypnotic effect is likely small.
What this interaction means in plain words
Armodafinil and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Zaleplon belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by armodafinil increases the minor oxidative metabolism of zaleplon.
What to do
No dose adjustment is needed routinely; review sleep response and adjust only if efficacy is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Zaleplon?
MediHelp rates the interaction as minor. Armodafinil and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a weak CYP3A4 inducer and may slightly reduce zaleplon exposure, since CYP3A4 is a minor pathway for zaleplon. Any loss of hypnotic effect is likely small.
How serious is the interaction between Armodafinil and Zaleplon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed routinely; review sleep response and adjust only if efficacy is inadequate.
What other medicines interact with Zaleplon?
MediHelp also lists interactions of Zaleplon with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Brexanolone. The full list is on the Zaleplon page.
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