Drug interactions
Artemether + Posaconazole
Severity: Contraindicated
Artemether and Posaconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and posaconazole may also increase artemether exposure. Together they raise the risk of torsades de pointes.
What this interaction means in plain words
Artemether and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive QT prolongation, plus CYP3A4 inhibition by posaconazole increasing artemether levels.
What to do
Avoid the combination; use a different antimalarial or antifungal. If unavoidable, obtain a baseline ECG and correct potassium and magnesium.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Posaconazole
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
- Dronedarone + Posaconazole Contraindicated
Frequently asked questions
Can I take Artemether with Posaconazole?
MediHelp rates the interaction as contraindicated. Artemether and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval, and posaconazole may also increase artemether exposure. Together they raise the risk of torsades de pointes.
How serious is the interaction between Artemether and Posaconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a different antimalarial or antifungal. If unavoidable, obtain a baseline ECG and correct potassium and magnesium.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Avanafil, Cobimetinib, Conivaptan. The full list is on the Posaconazole page.
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