Drug interactions
Artemether / lumefantrine + Eletriptan
Severity: Minor
Artemether / lumefantrine and Eletriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether and lumefantrine can induce CYP3A4 and may reduce eletriptan exposure. The result could be a weaker migraine response. Any effect is likely modest because antimalarial courses are short.
What this interaction means in plain words
Artemether / lumefantrine and Eletriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP3A4-mediated eletriptan metabolism.
What to do
No dose change is usually required. If eletriptan seems less effective during the antimalarial course, consider an alternative acute migraine therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Artemether / lumefantrine with Eletriptan?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Eletriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether and lumefantrine can induce CYP3A4 and may reduce eletriptan exposure. The result could be a weaker migraine response. Any effect is likely modest because antimalarial courses are short.
How serious is the interaction between Artemether / lumefantrine and Eletriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required. If eletriptan seems less effective during the antimalarial course, consider an alternative acute migraine therapy.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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