Drug interactions
Artemether / lumefantrine + Estradiol
Severity: Moderate
Artemether / lumefantrine and Estradiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether has weak CYP3A4 inducing activity and could slightly lower estradiol exposure during a short antimalarial course. This could reduce estrogen effect, and for hormonal contraceptives it could lower contraceptive reliability.
What this interaction means in plain words
Artemether / lumefantrine and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4-mediated estradiol metabolism by artemether.
What to do
Monitor for loss of estrogen effect such as breakthrough bleeding or return of vasomotor symptoms. If estradiol is used for contraception, advise a backup non-hormonal method during treatment and for the following week.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Artemether / lumefantrine with Estradiol?
MediHelp rates the interaction as moderate. Artemether / lumefantrine and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Artemether has weak CYP3A4 inducing activity and could slightly lower estradiol exposure during a short antimalarial course. This could reduce estrogen effect, and for hormonal contraceptives it could lower contraceptive reliability.
How serious is the interaction between Artemether / lumefantrine and Estradiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of estrogen effect such as breakthrough bleeding or return of vasomotor symptoms. If estradiol is used for contraception, advise a backup non-hormonal method during treatment and for the following week.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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