Drug interactions
Artemether / lumefantrine + Everolimus
Severity: Moderate
Artemether / lumefantrine and Everolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether/lumefantrine can weakly induce CYP3A4 and may lower everolimus exposure, potentially reducing efficacy or graft protection. Lumefantrine is also itself a CYP3A4 substrate. The effect is likely modest with a short antimalarial course.
What this interaction means in plain words
Artemether / lumefantrine and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Artemether induces CYP3A4, which increases the metabolic clearance of everolimus.
What to do
Monitor everolimus trough concentrations during and after the antimalarial course in transplant patients and adjust the dose accordingly. In oncology, watch for loss of effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Artemether / lumefantrine and Everolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Artemether / lumefantrine with Everolimus?
MediHelp rates the interaction as moderate. Artemether / lumefantrine and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Artemether/lumefantrine can weakly induce CYP3A4 and may lower everolimus exposure, potentially reducing efficacy or graft protection. Lumefantrine is also itself a CYP3A4 substrate. The effect is likely modest with a short antimalarial course.
How serious is the interaction between Artemether / lumefantrine and Everolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough concentrations during and after the antimalarial course in transplant patients and adjust the dose accordingly. In oncology, watch for loss of effect.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
