Drug interactions
Artemether / lumefantrine + Goserelin
Severity: Major
Artemether / lumefantrine and Goserelin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether/lumefantrine can prolong the QT interval, and goserelin may add to this through androgen deprivation. Combined use raises the risk of torsades de pointes.
What this interaction means in plain words
Artemether / lumefantrine and Goserelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation from androgen deprivation (goserelin) and delayed repolarization (lumefantrine).
What to do
Obtain a baseline ECG and correct potassium and magnesium. Monitor the QTc, or choose an alternative antimalarial if the QTc is prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Goserelin
- Amisulpride + Goserelin Major
- Arsenic trioxide + Goserelin Major
- Bedaquiline + Goserelin Major
- Ceritinib + Goserelin Major
- Disopyramide + Goserelin Major
- Dofetilide + Goserelin Major
Frequently asked questions
Can I take Artemether / lumefantrine with Goserelin?
MediHelp rates the interaction as major. Artemether / lumefantrine and Goserelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Artemether/lumefantrine can prolong the QT interval, and goserelin may add to this through androgen deprivation. Combined use raises the risk of torsades de pointes.
How serious is the interaction between Artemether / lumefantrine and Goserelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium. Monitor the QTc, or choose an alternative antimalarial if the QTc is prolonged.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Bedaquiline. The full list is on the Goserelin page.
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