Drug interactions
Ceritinib + Goserelin
Severity: Major
Ceritinib and Goserelin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib causes dose-dependent QT prolongation, and goserelin may add to the effect. The combination can increase the chance of torsades de pointes, particularly with bradycardia or electrolyte abnormalities.
What this interaction means in plain words
Ceritinib and Goserelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ceritinib belongs to Oncology; Goserelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor ECG and electrolytes at baseline and periodically during treatment. Reduce or withhold ceritinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Goserelin
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Goserelin?
MediHelp rates the interaction as major. Ceritinib and Goserelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ceritinib causes dose-dependent QT prolongation, and goserelin may add to the effect. The combination can increase the chance of torsades de pointes, particularly with bradycardia or electrolyte abnormalities.
How serious is the interaction between Ceritinib and Goserelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and periodically during treatment. Reduce or withhold ceritinib if QTc becomes markedly prolonged.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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