Drug interactions
Amisulpride + Goserelin
Severity: Major
Amisulpride and Goserelin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Goserelin-induced androgen deprivation can prolong the QT interval, and amisulpride causes dose-dependent QT prolongation. Combined use raises the risk of torsades de pointes.
What this interaction means in plain words
Amisulpride and Goserelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Goserelin belongs to Endocrine.
Why it happens
Additive QT prolongation through androgen deprivation and direct cardiac repolarization effects.
What to do
Avoid the combination if an alternative exists. Otherwise obtain a baseline ECG, monitor the QTc, and correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Goserelin
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Goserelin?
MediHelp rates the interaction as major. Amisulpride and Goserelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Goserelin-induced androgen deprivation can prolong the QT interval, and amisulpride causes dose-dependent QT prolongation. Combined use raises the risk of torsades de pointes.
How serious is the interaction between Amisulpride and Goserelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists. Otherwise obtain a baseline ECG, monitor the QTc, and correct potassium and magnesium abnormalities.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Arsenic trioxide, Artemether / lumefantrine, Bedaquiline. The full list is on the Goserelin page.
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